Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764904 | 0.77 | ALOX5 (0.49) | ALOX5KDM4EMAOAALDH1A1NPSR1 | |
| SCHEMBL3798516 | 0.77 | ALOX5 (0.57) | ALOX5KDM4EMAOADRD4HDAC8 | |
| SCHEMBL10611629 | 0.76 | HTR1A (0.47) | ALOX5HDAC8 | |
| SCHEMBL10611641 | 0.76 | HTR1A (0.47) | ALOX5HDAC8 | |
| SCHEMBL8374054 | 0.76 | ALOX5 (0.55) | ALOX5KDM4EDRD4SLC11A2ALDH1A1 | |
| SCHEMBL9443934 | 0.76 | ALOX5 (0.44) | ALOX5KDM4EMCL1ALDH1A1PPARG | |
| SCHEMBL9764922 | 0.75 | ALOX5 (0.49) | ALOX5KDM4EALDH1A1NPSR1 | |
| SCHEMBL20402334 | 0.74 | ALOX5 (0.55) | ALOX5KDM4EDRD4HDAC8MCL1 | |
| SCHEMBL7978519 | 0.74 | ALOX5 (0.62) | ALOX5KDM4EDRD4HDAC8MCL1 | |
| SCHEMBL9764814 | 0.74 | ALOX5 (0.45) | ALOX5MCL1CYP19A1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |