Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.45 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | GPR3 | P46089 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | OGG1 | O15527 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764829 | 0.78 | ALOX5 (0.41) | ALOX5LIMK1IKBKBGPR3 | |
| SCHEMBL9764833 | 0.76 | ALOX5 (0.43) | ALOX5LIMK1IKBKBGPR3OGG1 | |
| SCHEMBL9764866 | 0.76 | ALOX5 (0.43) | ALOX5LIMK1IKBKBGPR3 | |
| SCHEMBL9764888 | 0.74 | ALOX5 (0.75) | ALOX5MCL1CYP19A1MTNR1A | |
| SCHEMBL20402087 | 0.73 | MCL1 (0.47) | PARP14MCL1 | |
| SCHEMBL9764883 | 0.73 | ALOX5 (0.39) | ALOX5PARP14MCL1LIMK1SLC9A1 | |
| SCHEMBL9764825 | 0.73 | SLC9A1 (0.33) | ALOX5SLC9A1 | |
| SCHEMBL2957618 | 0.72 | GPR3 (0.50) | ALOX5PARP14MCL1CYP19A1GPR3 | |
| SCHEMBL11192918 | 0.72 | TDP1 (0.54) | ALOX5PARP14MCL1CYP19A1GPR3 | |
| SCHEMBL19768711 | 0.71 | GPR3 (0.45) | ALOX5PARP14MCL1CYP19A1GPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0346939-A1 | Tricyclic lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-12-20 | — | — | EP | disclosed |
| US-4822811-A | Carbazole lipoxygenase inhibiting compounds, compositions and use | ABBOTT LABORATORIES (US) | 1989-04-18 | — | — | US | disclosed |