Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764967 | 0.86 | POLB (0.51) | P2RX4LMNAMAPTALDH1A1HPGD | |
| SCHEMBL9764822 | 0.80 | POLB (0.46) | LMNAMAPTHTTMEN1ALDH1A1 | |
| SCHEMBL872109 | 0.73 | P2RX4 (0.81) | P2RX4LMNAMAPTHTTMEN1 | |
| SCHEMBL9764930 | 0.72 | ALOX5 (0.51) | P2RX4LMNAMAPTHTTMEN1 | |
| SCHEMBL9374562 | 0.71 | ATM (0.49) | ALDH1A1ALOX5 | |
| SCHEMBL9373618 | 0.70 | ALOX5 (0.57) | MEN1KMT2AALOX5 | |
| SCHEMBL9764866 | 0.70 | ALOX5 (0.43) | LMNAMAPTHTTALDH1A1HPGD | |
| SCHEMBL9764861 | 0.70 | KDM4E (0.51) | MAPTMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL12034344 | 0.70 | P2RX4 (0.61) | P2RX4LMNAMAPTHTTMEN1 | |
| SCHEMBL5324367 | 0.70 | PPARG (0.50) | P2RX4LMNAMAPTHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0346939-A1 | Tricyclic lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-12-20 | — | — | EP | disclosed |
| US-4822811-A | Carbazole lipoxygenase inhibiting compounds, compositions and use | ABBOTT LABORATORIES (US) | 1989-04-18 | — | — | US | disclosed |