Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.36 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764967 | 0.84 | POLB (0.51) | POLBMAPTNPY5RKDM4ELMNA | |
| SCHEMBL9764827 | 0.82 | ALDH1A1 (0.54) | POLBMAPTKDM4ELMNAMAPK1 | |
| SCHEMBL9764927 | 0.80 | P2RX4 (0.47) | POLBMAPTKDM4ELMNAMAPK1 | |
| SCHEMBL24667919 | 0.76 | KMT2A (0.51) | POLBMAPTNPY5RKDM4ELMNA | |
| SCHEMBL10559855 | 0.74 | ALOX5 (0.52) | NPY5RKMT2AMEN1 | |
| SCHEMBL4727525 | 0.74 | MEN1 (0.55) | POLBMAPTNPY5RKDM4ERORC | |
| SCHEMBL29643278 | 0.74 | MEN1 (0.55) | POLBMAPTNPY5RKDM4ERORC | |
| SCHEMBL4726731 | 0.72 | KMT2A (0.54) | POLBMAPTNPY5RKDM4ELMNA | |
| SCHEMBL9764866 | 0.71 | ALOX5 (0.43) | MAPTKDM4ELMNAALDH1A1HPGD | |
| SCHEMBL9764861 | 0.71 | KDM4E (0.51) | MAPTNPY5RKDM4ERORCKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |