Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.39 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.39 |
| ▸ | GPR3 | P46089 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764833 | 0.92 | ALOX5 (0.43) | ALOX5CYP1A2MAPTGPR3IKBKB | |
| SCHEMBL10559630 | 0.84 | ALOX5 (0.42) | ALOX5CYP1A2MAPTGPR3IKBKB | |
| SCHEMBL9764829 | 0.81 | ALOX5 (0.41) | ALOX5CYP1A2MAPTPTPN7DUSP3 | |
| SCHEMBL9764852 | 0.81 | PLA2G10 (0.40) | ALOX5 | |
| SCHEMBL9764861 | 0.78 | KDM4E (0.51) | MAPTALDH1A1HPGDRAB9AGABRP | |
| Ammonia Solution, Strong SCHEMBL9764837 | 0.77 | ALDH1A1 (0.39) | ALOX5CYP1A2MAPTPTPN7DUSP3 | |
| SCHEMBL9764870 | 0.76 | ALDH1A1 (0.38) | ALOX5CYP1A2MAPTGPR3ALDH1A1 | |
| SCHEMBL9764814 | 0.76 | ALOX5 (0.45) | ALOX5GPR3IKBKBLIMK1 | |
| SCHEMBL19768707 | 0.76 | GPR3 (0.56) | CYP1A2MAPTPTPN7DUSP3PTPN12 | |
| SCHEMBL7821341 | 0.76 | CYP1A2 (0.62) | CYP1A2MAPTPTPN7DUSP3PTPN12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |