Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 2/20 | 0.46 |
| ▸ | ALB | P02768 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.41 |
| ▸ | ACER2 | Q5QJU3 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11139267 | 0.80 | MEN1 (0.54) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL9192201 | 0.80 | ALDH1A1 (0.49) | NPSR1ALDH1A1MAPK1EGFRHDAC1 | |
| SCHEMBL9765055 | 0.77 | SOAT1 (0.63) | — | |
| SCHEMBL9765051 | 0.76 | TP53 (0.43) | ICMTALBCA12CA1CA2 | |
| SCHEMBL26607386 | 0.74 | MAPT (0.53) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL29052342 | 0.74 | MEN1 (0.53) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL25276969 | 0.72 | CA12 (0.64) | ICMTALBCA12CA1CA2 | |
| SCHEMBL9435656 | 0.72 | CA12 (0.64) | ICMTALBCA12CA1CA2 | |
| SCHEMBL22781563 | 0.72 | MAPT (0.67) | ICMTALBMEN1KMT2ANPSR1 | |
| SCHEMBL22305952 | 0.71 | MAPT (0.70) | ICMTALBMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994465-A | Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds | WARNER-LAMBERT COMPANY (US) | 1991-02-19 | — | — | US | disclosed |
| EP-0384320-A1 | Antihyperlipidemic and anti-atherosclerotic trisubstituted urea compounds | WARNER-LAMBERT COMPANY (US) | 1990-08-29 | — | — | EP | disclosed |