Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | KDM4B | O94953 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6827665 | 0.79 | CYP1B1 (0.41) | CYP1B1KMT2AMAPTTDP1STS | |
| SCHEMBL6827603 | 0.78 | TDP1 (0.49) | NR1I2CYP1B1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL6824269 | 0.78 | CYP1B1 (0.40) | CYP1B1KDM4EKMT2AMAPTALDH1A1 | |
| SCHEMBL6829397 | 0.78 | CYP1B1 (0.40) | CYP1B1KDM4EKMT2AMAPTALDH1A1 | |
| SCHEMBL6827998 | 0.78 | TDP1 (0.49) | NR1I2CYP1B1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL6829613 | 0.76 | TDP1 (0.50) | CYP1B1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL6829521 | 0.76 | CYP1B1 (0.38) | CYP1B1KDM4EKMT2AMAPTLMNA | |
| SCHEMBL31266000 | 0.74 | CYP1B1 (0.45) | CYP1B1MAPTCDK4CCND1STS | |
| SCHEMBL10161220 | 0.74 | ADCY8 (0.38) | CYP1B1STS | |
| SCHEMBL18696087 | 0.73 | CYP1B1 (0.46) | CYP1B1KDM4EKMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12220399-B2 | Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases | Adiptotec, Inc. (US) | 2025-02-11 | — | — | US | claimed |
| US-20230136999-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING ONE OR MORE PYRONE COMPOUNDS, AND THEIR USE FOR TREATING INFLAMMATORY AND NEURODEGENERATIVE DISEASES | Neuro TheryX Canada LTD (CA) | 2023-05-04 | — | — | US | claimed |
| US-11433047-B2 | Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases | NEUROTHERYX CANADA LTD. (CA) | 2022-09-06 | — | — | US | claimed |
| US-20170100369-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING ONE OR MORE PYRONE COMPOUNDS, AND THEIR USE FOR TREATING INFLAMMATORY AND NEURODEGENERATIVE DISEASES | BIOTHERYX, INC. | 2017-04-13 | — | — | US | claimed |
| US-12220399-B2 | Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases | Adiptotec, Inc. (US) | 2025-02-11 | — | — | US | disclosed |
| US-20230136999-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING ONE OR MORE PYRONE COMPOUNDS, AND THEIR USE FOR TREATING INFLAMMATORY AND NEURODEGENERATIVE DISEASES | Neuro TheryX Canada LTD (CA) | 2023-05-04 | — | — | US | disclosed |
| US-11433047-B2 | Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases | NEUROTHERYX CANADA LTD. (CA) | 2022-09-06 | — | — | US | disclosed |
| CN-104744359-B | A kind of process for purification of Ciclopirox | 上药康丽（常州）药业有限公司 | 2017-10-10 | — | — | CN | disclosed |
| US-20170100369-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING ONE OR MORE PYRONE COMPOUNDS, AND THEIR USE FOR TREATING INFLAMMATORY AND NEURODEGENERATIVE DISEASES | BIOTHERYX, INC. | 2017-04-13 | — | — | US | disclosed |
| CN-104873459-A | Ciclopirox olamine vaginal suppository | YANTAI RONGCHANG PHARMACEUTICAL CO LTD | 2015-09-02 | — | — | CN | disclosed |
| CN-104856942-A | Ciclopirox pessary and preparation method thereof | YANTAI RONGCHANG PHARMACEUTICAL CO LTD | 2015-08-26 | — | — | CN | disclosed |
| CN-104744359-A | Ciclopirox refining method | CHANGZHOU KONY PHARMACEUTICAL CO LTD | 2015-07-01 | — | — | CN | disclosed |
| EP-0255689-B1 | PROCESS FOR THE PREPARATION OF 1-HYDROXY-2-PYRIDINONES | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-11-21 | — | — | EP | disclosed |
| US-4916228-A | HYDROXYLAMMONIUM SLT AND PYRONE | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-04-10 | — | — | US | disclosed |
| EP-0255689-A2 | Process for the preparation of 1-hydroxy-2-pyridinones | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-02-10 | — | — | EP | disclosed |
| US-3972888-A | Process for the preparation of 1-hydroxy-pyridones | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170100369-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING ONE OR MORE PYRONE COMPOUNDS, AND THEIR USE FOR TREATING INFLAMMATORY AND NEURODEGENERATIVE DISEASES | PSEN1, NLRP3, PSEN2 | CA1 2755/4885CA9 3047/4885NR1I2 575/4885 |
| US-20230136999-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING ONE OR MORE PYRONE COMPOUNDS, AND THEIR USE FOR TREATING INFLAMMATORY AND NEURODEGENERATIVE DISEASES | PSEN1, NLRP3, PSEN2 | CA1 2755/4885CA9 3047/4885NR1I2 575/4885 |
| US-12220399-B2 | Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases | PSEN1, NLRP3, PSEN2 | CA1 2755/4885CA9 3047/4885NR1I2 575/4885 |
| US-11433047-B2 | Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases | PSEN1, NLRP3, PSEN2 | CA1 2755/4885CA9 3047/4885NR1I2 575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.