Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667255 | 0.84 | CYP1A2 (0.41) | KDM4ECYP2D6CYP1A2PKMSMN1; SMN2 | |
| SCHEMBL8520662 | 0.83 | APAF1 (0.59) | APAF1KDM4EPOLBMAPTRECQL | |
| SCHEMBL29501710 | 0.81 | SMN1; SMN2 (0.48) | KDM4ECYP2D6CYP1A2PKMSMN1; SMN2 | |
| SCHEMBL8985113 | 0.78 | APAF1 (0.51) | APAF1KDM4EPOLBMAPTRECQL | |
| SCHEMBL19383017 | 0.78 | CYP1A2 (0.43) | KDM4EMAPTL3MBTL1CYP2D6CYP1A2 | |
| Benzyl Carbamate SCHEMBL5783812 | 0.77 | ALDH1A1 (0.56) | L3MBTL1CYP2D6CYP1A2PKMSMN1; SMN2 | |
| SCHEMBL19143527 | 0.76 | KDM4E (0.49) | APAF1KDM4EPOLBMAPTRECQL | |
| SCHEMBL17208244 | 0.76 | CYP1A2 (0.42) | KDM4ECYP2D6CYP1A2PKMSMN1; SMN2 | |
| SCHEMBL28797485 | 0.75 | APAF1 (0.51) | APAF1KDM4EPOLBMAPTRECQL | |
| SCHEMBL4618502 | 0.74 | SMN1; SMN2 (0.51) | KDM4EL3MBTL1CYP2D6CYP1A2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5047425-A | Amine derivatives having cardiovascular activity | SIMES SOCIETA ITALIANA MEDICINALI & SINTETICI SPA (IT) | 1991-09-10 | — | — | US | disclosed |