Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13484174 | 0.81 | HPGD (0.47) | HPGDTSHRGRM2BRD4PREP | |
| SCHEMBL9766998 | 0.80 | HPGD (0.46) | HPGDTSHRGRM2BRD4PREP | |
| SCHEMBL3185962 | 0.78 | DPP4 (0.50) | HPGDTSHRGRM2BRD4SIRT1 | |
| SCHEMBL3201687 | 0.78 | DPP4 (0.50) | HPGDTSHRGRM2BRD4SIRT1 | |
| SCHEMBL3201676 | 0.78 | DPP4 (0.50) | HPGDTSHRGRM2BRD4SIRT1 | |
| SCHEMBL27623771 | 0.78 | BRD4 (0.47) | HPGDTSHRGRM2BRD4PREP | |
| SCHEMBL3179986 | 0.76 | CCKBR (0.52) | HPGDTSHRGRM2BRD4PREP | |
| SCHEMBL9803167 | 0.76 | HPGD (0.43) | HPGDTSHRGRM2BRD4PREP | |
| SCHEMBL9802568 | 0.76 | HPGD (0.43) | HPGDTSHRGRM2BRD4PREP | |
| SCHEMBL9803156 | 0.76 | HPGD (0.43) | HPGDTSHRGRM2BRD4PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996224-A | 1-benzyl-4- or 5-pyrrolidinomethyl-pyrrolidin-2-ones and nootropic method of use thereof | BOEHRINGER INGELHEIM KG (DE) | 1991-02-26 | — | — | US | disclosed |
| US-4767759-A | ANTIHYPOXICS | BOEHRINGER INGELHEIM KG (DE) | 1988-08-30 | — | — | US | disclosed |