Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | KDM6B | O15054 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9195257 | 0.78 | ROCK1 (0.52) | MEN1ALDH1A1KMT2AKDM4CROCK1 | |
| Hydrochloric Acid SCHEMBL9767541 | 0.77 | ROCK1 (0.51) | MEN1ALDH1A1KMT2AKDM4CROCK1 | |
| SCHEMBL9196015 | 0.72 | ALDH1A1 (0.52) | MEN1ALDH1A1KMT2AKDM4CPOLB | |
| SCHEMBL9193973 | 0.69 | ROCK1 (0.50) | MEN1ALDH1A1KMT2AROCK1POLB | |
| SCHEMBL9192032 | 0.69 | EED (0.52) | MEN1ALDH1A1KMT2AROCK1POLB | |
| SCHEMBL1102659 | 0.69 | ROCK1 (0.48) | ALDH1A1KMT2AKDM4CROCK1NUDT1 | |
| SCHEMBL26103577 | 0.68 | SMN1; SMN2 (0.48) | MEN1ALDH1A1KMT2AROCK1POLB | |
| SCHEMBL9767604 | 0.68 | ALOX15 (0.51) | MEN1ALDH1A1KMT2AKDM4CROCK1 | |
| Maleic Acid SCHEMBL9767806 | 0.67 | ALDH1A1 (0.46) | ALDH1A1KDM4CKDM6BPOLBL3MBTL1 | |
| Fumaric Acid SCHEMBL9767822 | 0.67 | ALDH1A1 (0.46) | ALDH1A1KDM4CKDM6BPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992448-A | Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-02-12 | — | — | US | claimed |
| US-5037835-A | Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0428878-A2 | Benzocycloalkylaminopyridinamines and related compounds, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4992448-A | Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-02-12 | — | — | US | disclosed |