Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9767613 | 0.80 | KDM4C (0.47) | ALOX15ALDH1A1SMN1; SMN2TP53NPC1 | |
| SCHEMBL9191760 | 0.79 | ROCK1 (0.50) | ALOX15ALDH1A1SMN1; SMN2TP53NPC1 | |
| SCHEMBL26103577 | 0.78 | SMN1; SMN2 (0.48) | ALOX15ALDH1A1SMN1; SMN2TP53NPC1 | |
| SCHEMBL9193973 | 0.76 | ROCK1 (0.50) | ALOX15ALDH1A1SMN1; SMN2TP53NPC1 | |
| SCHEMBL9196015 | 0.76 | ALDH1A1 (0.52) | ALOX15ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL9197156 | 0.72 | ALDH1A1 (0.53) | ALOX15ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL10546524 | 0.71 | L3MBTL1 (0.55) | SMN1; SMN2TP53RAB9ALMNAMAPK1 | |
| SCHEMBL15819819 | 0.71 | CYP11B2 (0.51) | ALOX15ALDH1A1SMN1; SMN2TP53NPC1 | |
| Maleic Acid SCHEMBL9767806 | 0.71 | ALDH1A1 (0.46) | ALOX15ALDH1A1SMN1; SMN2TP53NPC1 | |
| Fumaric Acid SCHEMBL9767822 | 0.71 | ALDH1A1 (0.46) | ALOX15ALDH1A1SMN1; SMN2TP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992448-A | Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-02-12 | — | — | US | claimed |
| US-5037835-A | Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0428878-A2 | Benzocycloalkylaminopyridinamines and related compounds, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4992448-A | Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-02-12 | — | — | US | disclosed |