Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.52 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.49 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.49 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitrobenzene SCHEMBL23406805 | 0.87 | ALDH1A1 (0.61) | ALDH1A1LMNASLC1A3SLC1A2SLC1A1 | |
| P-Nitrophenol SCHEMBL4805916 | 0.87 | SLC1A3 (0.50) | ALDH1A1SLC7A5SLC1A3SLC1A2SLC1A1 | |
| 4-Nitroaniline SCHEMBL29058965 | 0.87 | ALDH1A1 (0.58) | ALDH1A1SLC7A5SLC1A3SLC1A2SLC1A1 | |
| Valine SCHEMBL10510346 | 0.85 | SLC1A3 (0.49) | SLC7A5SLC1A3SLC1A2SLC1A1CES1 | |
| Nitrobenzene SCHEMBL28246897 | 0.83 | ALDH1A1 (0.55) | ALDH1A1LMNASLC1A3SLC1A2SLC1A1 | |
| Nitrobenzene SCHEMBL28483988 | 0.82 | ALDH1A1 (0.64) | ALDH1A1LMNACES2CES1HPGD | |
| Paranitrobenzyl Alcohol SCHEMBL5724094 | 0.82 | SLC1A3 (0.46) | LMNASLC7A5SLC1A3SLC1A2SLC1A1 | |
| Valine SCHEMBL15057374 | 0.80 | SLC7A5 (0.48) | ALDH1A1LMNASLC7A5SLC1A3SLC1A2 | |
| Valine SCHEMBL7169984 | 0.80 | TSHR (0.53) | ALDH1A1SLC7A5L3MBTL1NPC1RAB9A | |
| Nitrobenzene SCHEMBL11333335 | 0.79 | ALDH1A1 (0.73) | ALDH1A1LMNACES2CES1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931280-B1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS INC (US) | 2018-02-14 | — | — | EP | disclosed |
| US-9340532-B2 | Methods and compositions for inhibiting CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-20150307482-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2015-10-29 | — | — | US | disclosed |
| EP-2931280-A2 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | Phusis Therapeutics Inc. (US) | 2015-10-21 | — | — | EP | disclosed |
| WO-2014093988-A2 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2014-06-19 | — | — | WO | disclosed |
| US-5013354-A | Tetrahydrophthalimido group, herbicides | BASF AKTIENGESELLSCHAFT (DE) | 1991-05-07 | — | — | US | disclosed |
| EP-0300398-A2 | 3-Phenylpropionic acid derivatives | BASF Aktiengesellschaft (DE) | 1989-01-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307482-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | CNKSR1, CAMKK1, CAMKK2 | ALDH1A1 4764/4885LMNA 1352/4885SLC7A5 4839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.