Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10572167 | 1.00 | RAD52 (0.42) | RAD52ADAMTS5MAPTLMNAKDM4E | |
| SCHEMBL10572155 | 0.86 | POLB (0.36) | RAD52ADAMTS5MAPTLMNAKDM4E | |
| SCHEMBL10771121 | 0.75 | RAD52 (0.35) | RAD52ADAMTS5MAPTLMNAKDM4E | |
| SCHEMBL10371341 | 0.73 | RAD52 (0.54) | RAD52ADAMTS5MAPTLMNAKDM4E | |
| SCHEMBL9768384 | 0.73 | RAD52 (0.34) | RAD52MAPTALDH1A1PKM | |
| SCHEMBL10569643 | 0.73 | ALDH1A1 (0.41) | RAD52MAPTLMNATSHRALDH1A1 | |
| SCHEMBL9768382 | 0.73 | RAD52 (0.34) | RAD52MAPTALDH1A1PKM | |
| SCHEMBL10695401 | 0.71 | RAD52 (0.42) | RAD52ADAMTS5MAPTLMNAKDM4E | |
| SCHEMBL10674089 | 0.69 | BACE1 (0.37) | RAD52MAPTLMNATSHRALDH1A1 | |
| SCHEMBL15314930 | 0.68 | RAB9A (0.53) | RAD52ADAMTS5MAPTLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5025010-A | Benzothiazinone derivatives, and pharmaceuticals containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-06-18 | — | — | US | disclosed |
| EP-0300391-A1 | Benzothiazinone derivatives, process for their production, medicines containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-01-25 | — | — | EP | disclosed |