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Sugi Predict / Compounds / SCHEMBL976835

SCHEMBL976835

SCHEMBL976835

CC(C)(C)OC(=O)N1CC=C(c2ccc(Br)cn2)CC1

nearest known ligand 0.55

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ GRM1 Q13255 11/20 0.55
▸ GRM5 P41594 11/20 0.55
▸ WNT3A P56704 1/20 0.52
▸ PDK4 Q16654 1/20 0.50
▸ NAMPT P43490 2/20 0.47
▸ GPR119 Q8TDV5 1/20 0.45
▸ CYP11B2 P19099 1/20 0.45
▸ HTR6 P50406 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29746802 1.00 GRM1 (0.55) GRM1GRM5WNT3APDK4NAMPT
SCHEMBL31039781 1.00 GRM1 (0.55) GRM1GRM5WNT3APDK4NAMPT
SCHEMBL16554636 0.88 GRM1 (0.42) GRM1GRM5WNT3APDK4NAMPT
SCHEMBL903903 0.87 GRM1 (0.56) GRM1GRM5WNT3APDK4NAMPT
SCHEMBL13096687 0.86 GRM1 (0.55) GRM1GRM5WNT3APDK4NAMPT
SCHEMBL29907164 0.86 GRM1 (0.55) GRM1GRM5WNT3APDK4NAMPT
SCHEMBL1749492 0.86 GRM1 (0.55) GRM1GRM5WNT3APDK4NAMPT
SCHEMBL20266499 0.86 GRM1 (0.64) GRM1GRM5WNT3APDK4NAMPT
SCHEMBL30198712 0.86 GRM1 (0.55) GRM1GRM5WNT3APDK4NAMPT
SCHEMBL16340041 0.85 GRM1 (0.57) GRM1GRM5WNT3APDK4NAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078123-A1 PYRAZOLO[1,5-A]PYRIDINE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF SHANGHAI DAIDAI INVESTMENT CONSULTING CO., LTD (CN) 2026-03-19 — — US disclosed
US-12516054-B2 Pyrazolo[1,5-a]pyridine derivatives, preparation method therefor and use thereof SHANGHAI DAIDAI INVESTMENT CONSULTING CO., LTD (CN) 2026-01-06 — — US disclosed
CN-119431366-A IRAK4 degradation agent compound and application thereof 江苏先声药业有限公司 2025-02-14 — — CN disclosed
CN-118978537-A Pyrazolo [1,5-a ] pyridine derivative, preparation method and application thereof 上海岱岱投资咨询有限公司 2024-11-19 — — CN disclosed
WO-2024199341-A1 FUSED POLYCYCLIC DERIVATIVE AND USE THEREOF 浙江海正药业股份有限公司 2024-10-03 — — WO disclosed
US-12083124-B2 Bicyclic heterocycles as FGFR inhibitors INCYTE CORPORATION (US) 2024-09-10 — — US disclosed
US-11912699-B2 Tau-protein targeting compounds and associated ARVINAS OPERATIONS, INC. (US) 2024-02-27 — — US disclosed
US-11912699-B2 Tau-protein targeting compounds and associated ARVINAS OPERATIONS, INC. (US) 2024-02-27 — — US disclosed
US-20230338389-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION 2023-10-26 — — US disclosed
US-20230338389-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION 2023-10-26 — — US disclosed
US-20170008885-A1 PYRROLO[3,2-C]PYRIDINE DERIVATIVES AS TLR INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-01-12 — — US disclosed
EP-3080124-A1 PYRROLO[3,2-C]PYRIDINE DERIVATIVES AS TLR INHIBITORS Takeda Pharmaceutical Company Limited (JP) 2016-10-19 — — EP disclosed
US-9150555-B2 Amide derivative and use thereof MITSUBISHI TANABE PHARMA CORPORATION (JP) 2015-10-06 — — US disclosed
WO-2015088045-A1 PYRROLO[3,2-C]PYRIDINE DERIVATIVES AS TLR INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-06-18 — — WO disclosed
WO-2015034729-A1 SUBSTITUTED PYRIDINE COMPOUNDS AND METHODS OF USE CALITOR SCIENCES, LLC (US) 2015-03-12 — — WO disclosed
EP-2657230-A1 AMIDE DERIVATIVE AND USE THEREOF Mitsubishi Tanabe Pharma Corporation (JP) 2013-10-30 — — EP disclosed
US-20130211075-A1 AMIDE DERIVATIVE AND USE THEREOF MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-08-15 — — US disclosed
CN-103237800-A Amide derivatives and use thereof MITSUBISHI TANABE PHARMA CORP 2013-08-07 — — CN disclosed
US-8207344-B2 GPR119 agonists ELI LILLY AND COMPANY (US) 2012-06-26 — — US disclosed
US-20110015199-A1 GPR119 Agonists ELI LILLY AND COMPANY (US) 2011-01-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130211075-A1 AMIDE DERIVATIVE AND USE THEREOF IL2, IL4, IL5 GRM1 4147/4885GRM5 3247/4885WNT3A 4629/4885
US-12083124-B2 Bicyclic heterocycles as FGFR inhibitors FGFR1, FGFR3, FGFR2 GRM1 2117/4885GRM5 1935/4885WNT3A 2837/4885
US-20260078123-A1 PYRAZOLO[1,5-A]PYRIDINE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF NR3C1, CXCR1, CCR1 GRM1 227/4885GRM5 715/4885WNT3A 2017/4885
US-11912699-B2 Tau-protein targeting compounds and associated MAPT, VHL, CRBN GRM1 1490/4885GRM5 2329/4885WNT3A 1478/4885
US-20110015199-A1 GPR119 Agonists GPR119, GLP1R, GCGR GRM1 344/4885GRM5 332/4885WNT3A 1341/4885
US-20170008885-A1 PYRROLO[3,2-C]PYRIDINE DERIVATIVES AS TLR INHIBITORS TLR9, TLR7, TLR1 GRM1 928/4885GRM5 494/4885WNT3A 3542/4885
US-20230338389-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS FGFR1, FGFR3, FGFR2 GRM1 2117/4885GRM5 1935/4885WNT3A 2837/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.