Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.35 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.35 |
| ▸ | TYMP | P19971 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9768576 | 0.91 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2KMT2AKDM4EHSD17B10 | |
| SCHEMBL9768675 | 0.85 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2KMT2AKDM4EHSD17B10 | |
| SCHEMBL4500559 | 0.69 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2KMT2AKDM4EHPGD | |
| SCHEMBL17446140 | 0.67 | ALDH1A1 (0.54) | ALDH1A1KMT2AKDM4EHSD17B10HPGD | |
| SCHEMBL11125362 | 0.67 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2KMT2AKDM4EHSD17B10 | |
| SCHEMBL12066464 | 0.67 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2KMT2AKDM4EHSD17B10 | |
| SCHEMBL28829027 | 0.66 | ALDH1A1 (0.42) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL11125616 | 0.66 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2KMT2AKDM4EHPGD | |
| SCHEMBL10428820 | 0.65 | ADRA1D (0.34) | TYMP | |
| SCHEMBL17446072 | 0.65 | ALDH1A1 (0.51) | ALDH1A1KMT2AKDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5059601-A | IMIDAZOLONE DERIVATIVES WITH ACTIVITY ON CENTRAL NERVOUS SYSTEM AND ANTIHYPERTENSIVE ACTIVITY, PREPARATION METHODS THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ISTITUTO LUSOFARMACO D'ITALIA S.P.A. (IT) | 1991-10-22 | — | — | US | disclosed |
| EP-0379990-A1 | Imidazolone derivatives with activity on central nervous system and antihypertensive activity, preparation methods thereof, and pharmaceutical compositions containing them | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1990-08-01 | — | — | EP | disclosed |