Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.48 |
| ▸ | HPGD | P15428 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 2/20 | 0.33 |
| ▸ | GABRD | O14764 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9768587 | 0.85 | ALDH1A1 (0.48) | ALDH1A1HPGDMAPTNPSR1RXFP1 | |
| SCHEMBL4500559 | 0.83 | ALDH1A1 (0.48) | ALDH1A1HPGDMAPTNPSR1RXFP1 | |
| SCHEMBL11258178 | 0.80 | APEX1 (0.52) | ALDH1A1HPGDMAPTNPSR1RXFP1 | |
| SCHEMBL9768576 | 0.76 | ALDH1A1 (0.46) | ALDH1A1HPGDMAPTKDM4EGAA | |
| SCHEMBL28829027 | 0.76 | ALDH1A1 (0.42) | ALDH1A1HPGDMAPTNPSR1RXFP1 | |
| SCHEMBL28828985 | 0.74 | AVPR2 (0.41) | ALDH1A1HPGDMAPTNPSR1RXFP1 | |
| SCHEMBL28828981 | 0.74 | AVPR2 (0.41) | ALDH1A1HPGDMAPTNPSR1RXFP1 | |
| SCHEMBL28828879 | 0.73 | TSHR (0.50) | ALDH1A1HPGDMAPTNPSR1KDM4E | |
| SCHEMBL11126289 | 0.70 | ALDH1A1 (0.69) | ALDH1A1HPGDMAPTNPSR1RXFP1 | |
| SCHEMBL4496826 | 0.69 | DRD2 (0.38) | ALDH1A1HPGDMAPTNPSR1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5059601-A | IMIDAZOLONE DERIVATIVES WITH ACTIVITY ON CENTRAL NERVOUS SYSTEM AND ANTIHYPERTENSIVE ACTIVITY, PREPARATION METHODS THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ISTITUTO LUSOFARMACO D'ITALIA S.P.A. (IT) | 1991-10-22 | — | — | US | disclosed |
| EP-0379990-A1 | Imidazolone derivatives with activity on central nervous system and antihypertensive activity, preparation methods thereof, and pharmaceutical compositions containing them | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1990-08-01 | — | — | EP | disclosed |