Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9768587 | 0.91 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2PGRMAPK14KDM4E | |
| SCHEMBL9768675 | 0.76 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2KDM4EHSD17B10KMT2A | |
| SCHEMBL17446072 | 0.69 | ALDH1A1 (0.51) | ALDH1A1PGRKDM4EHSD17B10KMT2A | |
| SCHEMBL3792986 | 0.68 | SLC9A1 (0.47) | ADRA1AADRA1BADRA1D | |
| SCHEMBL7822379 | 0.68 | ADRA1A (0.50) | ADRA1AADRA1BADRA1D | |
| SCHEMBL4500559 | 0.67 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2PGRKDM4EKMT2A | |
| SCHEMBL7833004 | 0.67 | ADRA1D (0.43) | ADRA1AADRA1BADRA1D | |
| SCHEMBL11255916 | 0.65 | FABP4 (0.54) | ALDH1A1KDM4EHSD17B10KMT2AGLA | |
| SCHEMBL11267074 | 0.65 | FABP4 (0.54) | ALDH1A1KDM4EHSD17B10KMT2AGLA | |
| SCHEMBL11258884 | 0.65 | FABP4 (0.54) | ALDH1A1KDM4EHSD17B10KMT2AGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5059601-A | IMIDAZOLONE DERIVATIVES WITH ACTIVITY ON CENTRAL NERVOUS SYSTEM AND ANTIHYPERTENSIVE ACTIVITY, PREPARATION METHODS THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ISTITUTO LUSOFARMACO D'ITALIA S.P.A. (IT) | 1991-10-22 | — | — | US | disclosed |
| EP-0379990-A1 | Imidazolone derivatives with activity on central nervous system and antihypertensive activity, preparation methods thereof, and pharmaceutical compositions containing them | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1990-08-01 | — | — | EP | disclosed |