Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10444817 | 0.90 | KDM4E (0.48) | KDM4EALDH1A1HPGDCA12CA9 | |
| Hydrochloric Acid SCHEMBL9768887 | 0.89 | KDM4E (0.47) | KDM4EALDH1A1CA12CA9MAPT | |
| SCHEMBL9768706 | 0.84 | MAPT (0.44) | KDM4EALDH1A1CA9MAPTSLC6A2 | |
| SCHEMBL9768760 | 0.84 | KDM4E (0.48) | KDM4EALDH1A1HPGDCA12CA9 | |
| SCHEMBL9768709 | 0.76 | ALDH1A1 (0.43) | KDM4EALDH1A1MAPTSLC6A2SLC6A4 | |
| SCHEMBL9768826 | 0.74 | MAPT (0.41) | KDM4EALDH1A1MAPTSLC6A2SLC6A4 | |
| SCHEMBL9768744 | 0.74 | NR1I3 (0.44) | KDM4EALDH1A1MAPTNR1I3SMN1; SMN2 | |
| SCHEMBL9768684 | 0.74 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDCA12CA9 | |
| SCHEMBL9768774 | 0.73 | ALDH1A1 (0.43) | KDM4EALDH1A1MAPTSLC6A2SLC6A4 | |
| SCHEMBL9768732 | 0.72 | ALDH1A1 (0.44) | KDM4EALDH1A1MAPTSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011833-A | Antidepressant | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE (IT) | 1991-04-30 | — | — | US | disclosed |
| EP-0354885-A1 | Novel derivatives of 6,11-dihydro-dibenzo[c,f][1,2,5]-thiadiazepine 5,5-dioxide, salts thereof and appropriate processes for the preparation thereof | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1990-02-14 | — | — | EP | disclosed |