Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9768706 | 0.89 | MAPT (0.44) | MAPTKDM4ESLC6A2SLC6A4NR1I3 | |
| SCHEMBL9768774 | 0.87 | ALDH1A1 (0.43) | MAPTKDM4ESLC6A2SLC6A4NR1I3 | |
| SCHEMBL9768766 | 0.86 | NPC1 (0.45) | MAPTALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL9768709 | 0.83 | ALDH1A1 (0.43) | MAPTKDM4ESLC6A2SLC6A4NR1I3 | |
| Hydrochloric Acid SCHEMBL9768872 | 0.81 | ALDH1A1 (0.43) | MAPTKDM4ESLC6A2SLC6A4NR1I3 | |
| SCHEMBL9768732 | 0.79 | ALDH1A1 (0.44) | MAPTKDM4ESLC6A2SLC6A4NR1I3 | |
| SCHEMBL9768744 | 0.77 | NR1I3 (0.44) | MAPTKDM4ENR1I3ALDH1A1SMN1; SMN2 | |
| SCHEMBL9768823 | 0.77 | KDM4E (0.46) | MAPTKDM4ENR1I3ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL9768729 | 0.76 | MAPT (0.39) | MAPTKDM4ESLC6A2SLC6A4NR1I3 | |
| SCHEMBL9768974 | 0.76 | MAPT (0.41) | MAPTKDM4ESLC6A2SLC6A4NR1I3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011833-A | Antidepressant | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE (IT) | 1991-04-30 | — | — | US | claimed |
| US-5011833-A | Antidepressant | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE (IT) | 1991-04-30 | — | — | US | disclosed |