Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I3 | Q14994 | 10/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9768706 | 0.86 | MAPT (0.44) | NR1I3KDM4EMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9768785 | 0.81 | NPC1 (0.53) | ALDH1A1TP53 | |
| SCHEMBL9768823 | 0.79 | KDM4E (0.46) | NR1I3KDM4EMAPTPOLBALDH1A1 | |
| SCHEMBL9768762 | 0.78 | NPC1 (0.40) | MAPTALDH1A1TP53 | |
| SCHEMBL9768832 | 0.78 | MTNR1A (0.40) | GAAMAPTPOLBTP53 | |
| Hydrochloric Acid SCHEMBL9768695 | 0.78 | KDM4E (0.47) | NR1I3KDM4EMAPTSMN1; SMN2POLB | |
| SCHEMBL9768826 | 0.77 | MAPT (0.41) | NR1I3GAAKDM4ECYP2D6MAPT | |
| SCHEMBL9768831 | 0.76 | ALDH1A1 (0.56) | NR1I3GAAKDM4ECYP2D6MAPT | |
| SCHEMBL9768740 | 0.76 | CYP2D6 (0.53) | NR1I3KDM4ECYP2D6MAPTALDH1A1 | |
| SCHEMBL9768774 | 0.76 | ALDH1A1 (0.43) | NR1I3KDM4ECYP2D6MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011833-A | Antidepressant | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE (IT) | 1991-04-30 | — | — | US | claimed |
| US-5011833-A | Antidepressant | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE (IT) | 1991-04-30 | — | — | US | disclosed |
| EP-0354885-A1 | Novel derivatives of 6,11-dihydro-dibenzo[c,f][1,2,5]-thiadiazepine 5,5-dioxide, salts thereof and appropriate processes for the preparation thereof | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1990-02-14 | — | — | EP | disclosed |