Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 11/20 | 0.56 |
| ▸ | LMNA | P02545 | 7/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.56 |
| ▸ | HTR1A | P08908 | 7/20 | 0.56 |
| ▸ | DRD2 | P14416 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | HRH1 | P35367 | 6/20 | 0.56 |
| ▸ | HTR2A | P28223 | 5/20 | 0.56 |
| ▸ | HTR6 | P50406 | 5/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.56 |
| ▸ | DRD1 | P21728 | 5/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.56 |
| ▸ | DRD3 | P35462 | 5/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.56 |
| ▸ | MTOR | P42345 | 5/20 | 0.56 |
| ▸ | SLC22A1 | O15245 | 4/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1302641 | 0.85 | LMNA (0.58) | CYP2D6LMNASLC6A4HTR1ADRD2 | |
| SCHEMBL7805848 | 0.82 | TP53 (0.42) | LMNASLC6A4HTR1ADRD2MAPT | |
| Pretiadil SCHEMBL2734627 | 0.81 | SIGMAR1 (0.49) | CYP2D6LMNASLC6A4HTR1ADRD2 | |
| SCHEMBL7811781 | 0.76 | MEN1 (0.35) | LMNASLC6A4MAPTALDH1A1KDM4E | |
| SCHEMBL5153952 | 0.75 | MAPT (0.59) | CYP2D6LMNASLC6A4HTR1ADRD2 | |
| SCHEMBL9768823 | 0.74 | KDM4E (0.46) | LMNAMAPTALDH1A1KDM4ETP53 | |
| Hydrochloric Acid SCHEMBL9768695 | 0.73 | KDM4E (0.47) | LMNAMAPTALDH1A1SMN1; SMN2KDM4E | |
| Imipramine SCHEMBL17004048 | 0.72 | SLC6A4 (1.00) | CYP2D6LMNASLC6A4HTR1ADRD2 | |
| Imipramine SCHEMBL6118138 | 0.72 | SLC6A4 (1.00) | CYP2D6LMNASLC6A4HTR1ADRD2 | |
| Imipramine SCHEMBL34282 | 0.72 | SLC6A4 (1.00) | CYP2D6LMNASLC6A4HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011833-A | Antidepressant | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE (IT) | 1991-04-30 | — | — | US | disclosed |
| EP-0354885-A1 | Novel derivatives of 6,11-dihydro-dibenzo[c,f][1,2,5]-thiadiazepine 5,5-dioxide, salts thereof and appropriate processes for the preparation thereof | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1990-02-14 | — | — | EP | disclosed |