Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.57 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.57 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.57 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9769469 | 0.82 | DRD3 (0.51) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL9716422 | 0.79 | HPGD (0.46) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL7861253 | 0.76 | KCNH2 (0.78) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL7854083 | 0.75 | KCNH2 (0.72) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL9769468 | 0.75 | TDP1 (0.39) | KCNH2DRD3NPC1RAB9A | |
| SCHEMBL9769475 | 0.73 | KCNH2 (0.54) | KCNH2SMN1; SMN2MAPK1 | |
| Dofetilide SCHEMBL16135 | 0.73 | KCNH2 (1.00) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| Dofetilide SCHEMBL6102734 | 0.73 | KCNH2 (1.00) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL9716427 | 0.72 | MET (0.39) | KCNH2RAB9AHPGDSMN1; SMN2LMNA | |
| Dofetilide SCHEMBL8362214 | 0.72 | KCNH2 (0.97) | KCNH2CACNA1FCHRM2ACHEAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006561-A | Indane sulfonamide anti-arrhythmic agents and use | PFIZER INC. (US) | 1991-04-09 | — | — | US | disclosed |