Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 5/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.51 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9716422 | 0.87 | HPGD (0.46) | DRD3KCNH2CACNA1FCHRM2ACHE | |
| SCHEMBL9769480 | 0.82 | KCNH2 (0.57) | DRD3KCNH2CACNA1FCHRM2ACHE | |
| SCHEMBL9628026 | 0.78 | KCNH2 (0.76) | DRD3KCNH2CACNA1FCHRM2ACHE | |
| SCHEMBL9451561 | 0.76 | DRD3 (0.46) | DRD3KCNH2CACNA1FCHRM2ACHE | |
| SCHEMBL9080505 | 0.75 | KCNH2 (0.59) | DRD3KCNH2CACNA1FCHRM2ACHE | |
| SCHEMBL9080508 | 0.75 | CACNA1F (0.62) | DRD3KCNH2CACNA1FCHRM2ACHE | |
| SCHEMBL9716427 | 0.75 | MET (0.39) | KCNH2KDM4EHPGDALDH1A1LMNA | |
| SCHEMBL9769473 | 0.73 | SIGMAR1 (0.43) | DRD3GRIN2BDRD2 | |
| SCHEMBL9716415 | 0.72 | MMP2 (0.35) | HPGDMAPK1NR3C2GRIA2MCHR1 | |
| SCHEMBL9826819 | 0.72 | KCNH2 (0.67) | DRD3KCNH2CACNA1FCHRM2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006561-A | Indane sulfonamide anti-arrhythmic agents and use | PFIZER INC. (US) | 1991-04-09 | — | — | US | claimed |
| US-5006561-A | Indane sulfonamide anti-arrhythmic agents and use | PFIZER INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-5006561-A | Indane sulfonamide anti-arrhythmic agents and use | PFIZER INC. (US) | 1991-04-09 | — | — | US | disclosed |
| EP-0286278-A1 | Indanamine derivatives useful as antiarrhythmic agents | Pfizer Limited (GB) | 1988-10-12 | — | — | EP | disclosed |