Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | DRD3 | P35462 | 4/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9769473 | 0.79 | SIGMAR1 (0.43) | DRD2DRD3DRD4 | |
| SCHEMBL3466437 | 0.79 | DRD2 (0.43) | DRD2DRD3DRD4 | |
| SCHEMBL3466440 | 0.79 | DRD2 (0.43) | DRD2DRD3DRD4 | |
| SCHEMBL3467135 | 0.79 | DRD2 (0.43) | DRD2DRD3DRD4 | |
| SCHEMBL14484048 | 0.77 | NFE2L2 (0.56) | TDP1NFE2L2TSHR | |
| SCHEMBL12156434 | 0.77 | NFE2L2 (0.56) | TDP1NFE2L2TSHR | |
| SCHEMBL9769475 | 0.76 | KCNH2 (0.54) | KCNH2 | |
| SCHEMBL9716394 | 0.76 | HRH3 (0.41) | DRD2DRD3DRD4HRH3 | |
| SCHEMBL9769480 | 0.75 | KCNH2 (0.57) | DRD3NPC1RAB9AKCNH2 | |
| SCHEMBL2022333 | 0.74 | KCNH2 (0.56) | TDP1NFE2L2KEAP1TSHRDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006561-A | Indane sulfonamide anti-arrhythmic agents and use | PFIZER INC. (US) | 1991-04-09 | — | — | US | disclosed |
| EP-0286278-A1 | Indanamine derivatives useful as antiarrhythmic agents | Pfizer Limited (GB) | 1988-10-12 | — | — | EP | disclosed |