Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PNMT | P11086 | 4/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | LSS | P48449 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9769482 | 0.81 | SIGMAR1 (0.49) | KCNH2PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL14878929 | 0.79 | PNMT (0.55) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL9716410 | 0.79 | PNMT (0.48) | KCNH2PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL30561524 | 0.77 | PNMT (0.56) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL1640125 | 0.77 | PNMT (0.56) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL9769468 | 0.76 | TDP1 (0.39) | KCNH2 | |
| SCHEMBL1962562 | 0.74 | KCNH2 (0.68) | KCNH2CHRNB2CHRNA4GAAMAPT | |
| Hydrochloric Acid SCHEMBL3570004 | 0.73 | KCNH2 (0.67) | KCNH2CHRNB2CHRNA4GAALSS | |
| Hydrochloric Acid SCHEMBL8176570 | 0.73 | GRIN2B (0.49) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL9769480 | 0.73 | KCNH2 (0.57) | KCNH2MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1016506-B | Preparation method of 1, 2-indane sulfonamide compound with antiarrhythmic drug activity | PFIZER LTD (GB) | 1992-05-06 | — | — | CN | disclosed |
| US-5006561-A | Indane sulfonamide anti-arrhythmic agents and use | PFIZER INC. (US) | 1991-04-09 | — | — | US | disclosed |
| CN-1038449-A | Antiarrhythmics | PFIZER LTD (GB) | 1990-01-03 | — | — | CN | disclosed |
| EP-0286278-A1 | Indanamine derivatives useful as antiarrhythmic agents | Pfizer Limited (GB) | 1988-10-12 | — | — | EP | disclosed |