Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HMGCR | P04035 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9769841 | 0.88 | HMGCR (0.41) | ALDH1A1HPGDHMGCRHSD11B1MGLL | |
| SCHEMBL9769846 | 0.88 | HMGCR (0.41) | ALDH1A1HPGDHMGCRHSD11B1MGLL | |
| SCHEMBL9769874 | 0.81 | HMGCR (0.54) | ALDH1A1HPGDHMGCRHSD11B1MGAM | |
| SCHEMBL9769894 | 0.78 | ALDH1A1 (0.43) | ALDH1A1HPGDHMGCRHSD11B1MGLL | |
| SCHEMBL10437581 | 0.76 | HMGCR (0.53) | ALDH1A1HPGDHMGCRHSD11B1HDAC6 | |
| SCHEMBL10437579 | 0.76 | HMGCR (0.53) | ALDH1A1HPGDHMGCRHSD11B1HDAC6 | |
| SCHEMBL9769883 | 0.74 | HMGCR (0.77) | HMGCR | |
| SCHEMBL9769879 | 0.74 | HMGCR (0.77) | HMGCR | |
| SCHEMBL9769828 | 0.74 | ELANE (0.43) | ALDH1A1HPGDHSD11B1MGLLHDAC6 | |
| SCHEMBL9769858 | 0.72 | HMGCR (0.51) | ALDH1A1HPGDHMGCRKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5070206-A | INHIBITORS OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE; ANTICHOLESTEROL, ANTILIPEMIC | BRISTOL-MYERS COMPANY (US) | 1991-12-03 | — | — | US | disclosed |
| US-5010205-A | Antihypercholesterolemic tetrazol-1-yl intermediates | BRISTOL-MYERS COMPANY (US) | 1991-04-23 | — | — | US | disclosed |
| EP-0355820-A1 | Antihypercholesterolemic tetrazol-1-yl compounds | Bristol-Myers Squibb Company (US) | 1990-02-28 | — | — | EP | disclosed |
| US-4870187-A | ANTILIPEMIC, ATHEROSCLEROSIS | BRISTOL-MYERS COMPANY (US) | 1989-09-26 | — | — | US | disclosed |