Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | TOP1 | P11387 | 2/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27629739 | 0.88 | ALDH1A1 (0.41) | PTGS2CYP1A2HPGD | |
| SCHEMBL6880077 | 0.88 | ALDH1A1 (0.41) | PTGS2CYP1A2HPGD | |
| SCHEMBL445102 | 0.88 | ALDH1A1 (0.41) | PTGS2CYP1A2HPGD | |
| SCHEMBL618853 | 0.88 | BACE1 (0.39) | PTGS2HPGD | |
| SCHEMBL3870533 | 0.84 | BACE1 (0.36) | PTGS2HPGD | |
| SCHEMBL6474583 | 0.84 | BACE1 (0.36) | PTGS2HPGD | |
| SCHEMBL18832483 | 0.79 | ALDH1A1 (0.39) | PTGS2HPGD | |
| SCHEMBL27649740 | 0.79 | PTGS2 (0.57) | PTGS2PTGS1ADORA1NR4A2TOP1 | |
| SCHEMBL27707573 | 0.78 | PTGS2 (0.35) | PTGS2PTGS1NR4A2GCGRMAPK14 | |
| SCHEMBL693886 | 0.78 | MEN1 (0.35) | PTGS2PTGS1CYP1A2CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5051518-A | Antiinflammatory agents and cardiovascular disorders | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-09-24 | — | — | US | disclosed |