Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28080648 | 0.85 | HPGD (0.47) | KDM4EALDH1A1HPGDNPSR1ERN1 | |
| SCHEMBL27699813 | 0.75 | KDM4E (0.45) | KDM4EALDH1A1HPGDNPSR1ERN1 | |
| SCHEMBL11030727 | 0.74 | KDM4E (0.50) | KDM4EALDH1A1HPGDNPSR1ERN1 | |
| SCHEMBL14220489 | 0.74 | MAPT (0.34) | ALDH1A1L3MBTL1MAPTTP53 | |
| SCHEMBL10161335 | 0.73 | MTNR1A (0.36) | HPGDNPSR1L3MBTL1POLBMAPT | |
| SCHEMBL22978747 | 0.73 | KDM4E (0.60) | KDM4EALDH1A1HPGDNPSR1L3MBTL1 | |
| SCHEMBL10160471 | 0.72 | MAPT (0.42) | ALDH1A1HPGDNPSR1L3MBTL1TDP1 | |
| SCHEMBL24806042 | 0.72 | CYP1A1 (0.57) | KDM4EALDH1A1HPGDNPSR1L3MBTL1 | |
| SCHEMBL12948220 | 0.71 | ALDH1A1 (0.43) | KDM4EALDH1A1NPSR1L3MBTL1TDP1 | |
| SCHEMBL9250273 | 0.70 | MEN1 (0.61) | KDM4EALDH1A1HPGDTDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11192866-B2 | Synthesis of tetracyclines and analogues thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-12-07 | — | — | US | disclosed |
| EP-3138831-B1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | HARVARD COLLEGE (US) | 2020-07-08 | — | — | EP | disclosed |
| EP-2016044-B1 | PENTACYCLINE DERIVATIVES FOR THE TREATMENT OF INFECTIONS | HARVARD COLLEGE (US) | 2020-06-10 | — | — | EP | disclosed |
| US-10669244-B2 | Synthesis of tetracyclines and analogues thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-06-02 | — | — | US | disclosed |
| US-20190345116-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-11-14 | — | — | US | disclosed |
| US-9884830-B2 | Synthesis of tetracyclines and analogues thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-02-06 | — | — | US | disclosed |
| US-9884830-B2 | Synthesis of tetracyclines and analogues thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-02-06 | — | — | US | disclosed |
| EP-3138831-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | President and Fellows of Harvard College (US) | 2017-03-08 | — | — | EP | disclosed |
| EP-3138831-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | President and Fellows of Harvard College (US) | 2017-03-08 | — | — | EP | disclosed |
| US-20160340325-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-11-24 | — | — | US | disclosed |
| US-20100130451-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2010-05-27 | — | — | US | disclosed |
| EP-1753713-A4 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | HARVARD COLLEGE (US) | 2009-07-08 | — | — | EP | disclosed |
| EP-2016044-A2 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | The President and Fellows of Harvard College (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007117639-A9 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | HARVARD COLLEGE (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2007117639-A9 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | HARVARD COLLEGE (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2007117639-A2 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-10-18 | — | — | WO | disclosed |
| WO-2007117639-A2 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-10-18 | — | — | WO | disclosed |
| EP-1753713-A2 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | The President and Fellows of Harvard College (US) | 2007-02-21 | — | — | EP | disclosed |
| US-20050282787-A1 | Synthesis of tetracyclines and analogues thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2005-12-22 | — | — | US | disclosed |
| WO-2005112945-A2 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11192866-B2 | Synthesis of tetracyclines and analogues thereof | TET1, TET3, MYC | KDM4E 800/4885ALDH1A1 4455/4885HPGD 3373/4885 |
| US-20050282787-A1 | Synthesis of tetracyclines and analogues thereof | TET1, TET3, MYC | KDM4E 800/4885ALDH1A1 4455/4885HPGD 3373/4885 |
| US-20190345116-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | TET1, TET3, MYC | KDM4E 800/4885ALDH1A1 4455/4885HPGD 3373/4885 |
| US-20100130451-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | CCNE1, CCNE2, CCNT2 | KDM4E 328/4885ALDH1A1 4622/4885HPGD 2807/4885 |
| US-10669244-B2 | Synthesis of tetracyclines and analogues thereof | TET1, TET3, MYC | KDM4E 800/4885ALDH1A1 4455/4885HPGD 3373/4885 |
| US-20160340325-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | TET1, TET3, MYC | KDM4E 800/4885ALDH1A1 4455/4885HPGD 3373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.