Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9826922 | 0.76 | RAB9A (0.47) | KMT2AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL9771422 | 0.75 | EP300 (0.49) | TSHRKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL9771295 | 0.74 | TP53 (0.44) | KMT2ARIPK1GFER | |
| SCHEMBL9827539 | 0.73 | ALDH1A1 (0.36) | KMT2AL3MBTL1LMNAADORA3ALDH1A1 | |
| SCHEMBL9827209 | 0.73 | POLB (0.46) | TSHRKMT2ALMNAALDH1A1 | |
| SCHEMBL9771408 | 0.73 | KMT2A (0.42) | KMT2ALMNAALDH1A1 | |
| SCHEMBL9827161 | 0.73 | TSHR (0.50) | TSHRKMT2AL3MBTL1ALDH1A1GFER | |
| SCHEMBL9771337 | 0.71 | CMA1 (0.50) | KMT2AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL15371313 | 0.70 | BRD4 (0.35) | TSHRKMT2AL3MBTL1NR3C2NR3C1 | |
| SCHEMBL15371305 | 0.70 | BRD4 (0.35) | TSHRKMT2AL3MBTL1NR3C2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5068341-A | OPTICALLY ACTIVE HYDANTOINS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-11-26 | — | — | US | disclosed |
| EP-0243734-B1 | OPTICALLY ACTIVE HYDANTOIN | MERCK PATENT GmbH (DE) | 1991-07-17 | — | — | EP | disclosed |
| EP-0243734-A2 | Optically active hydantoin | MERCK PATENT GmbH (DE) | 1987-11-04 | — | — | EP | disclosed |