Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | CTSG | P08311 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | CTRC | Q99895 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9827209 | 0.87 | POLB (0.46) | TP53POLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL9827161 | 0.86 | TSHR (0.50) | POLBGAAMAPTKDM4EALDH1A1 | |
| SCHEMBL9826849 | 0.83 | MAPT (0.43) | POLBGAAHTTSMN1; SMN2MAPT | |
| SCHEMBL9827174 | 0.80 | TP53 (0.48) | RAB9ATP53POLBGAALMNA | |
| SCHEMBL9771408 | 0.79 | KMT2A (0.42) | TP53POLBLMNAF2ELANE | |
| SCHEMBL9771318 | 0.76 | TSHR (0.33) | LMNAALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL9827212 | 0.75 | GAA (0.77) | RAB9ATP53POLBGAALMNA | |
| SCHEMBL9771422 | 0.71 | EP300 (0.49) | POLBF2ELANECTSGCMA1 | |
| SCHEMBL15131571 | 0.70 | F2 (0.55) | RAB9AGAALMNAHTTF2 | |
| SCHEMBL9827539 | 0.69 | ALDH1A1 (0.36) | POLBGAALMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243734-B1 | OPTICALLY ACTIVE HYDANTOIN | MERCK PATENT GmbH (DE) | 1991-07-17 | — | — | EP | disclosed |
| EP-0243734-A2 | Optically active hydantoin | MERCK PATENT GmbH (DE) | 1987-11-04 | — | — | EP | disclosed |