Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | EP300 | Q09472 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | CTSG | P08311 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | CTRC | Q99895 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9771431 | 0.88 | TRPM8 (0.39) | ADORA2AALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL9771429 | 0.84 | CMA1 (0.52) | CMA1ALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL9771422 | 0.82 | EP300 (0.49) | ADORA2AEP300F2PLGELANE | |
| SCHEMBL9771408 | 0.77 | KMT2A (0.42) | ADORA2AEP300F2PLGELANE | |
| SCHEMBL9771398 | 0.75 | ADORA2A (0.48) | ADORA2AEP300F2PLGELANE | |
| SCHEMBL9771337 | 0.74 | CMA1 (0.50) | EP300CMA1ALDH1A1KMT2AMEN1 | |
| SCHEMBL17358741 | 0.72 | ELANE (0.67) | ADORA2AEP300F2PLGELANE | |
| SCHEMBL9771342 | 0.71 | POLB (0.46) | ALDH1A1KMT2AMEN1SMN1; SMN2POLB | |
| SCHEMBL17961704 | 0.69 | ADORA2A (0.48) | ADORA2AEP300F2PLGELANE | |
| SCHEMBL9482020 | 0.69 | ADORA2A (0.48) | ADORA2AEP300F2PLGELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5068341-A | OPTICALLY ACTIVE HYDANTOINS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-11-26 | — | — | US | disclosed |
| EP-0243734-B1 | OPTICALLY ACTIVE HYDANTOIN | MERCK PATENT GmbH (DE) | 1991-07-17 | — | — | EP | disclosed |
| EP-0243734-A2 | Optically active hydantoin | MERCK PATENT GmbH (DE) | 1987-11-04 | — | — | EP | disclosed |