Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 11/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GNRHR | P30968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9771974 | 0.95 | TBXA2R (0.52) | TBXA2RAGTR1AGTR2P2RX3KDM4E | |
| SCHEMBL9777414 | 0.81 | GALR3 (0.50) | TBXA2RKDM4EALDH1A1 | |
| SCHEMBL9581575 | 0.80 | TBXA2R (0.58) | TBXA2RAGTR1AGTR2MAPK1NPSR1 | |
| SCHEMBL9682472 | 0.79 | TBXA2R (0.57) | TBXA2RAGTR1AGTR2GNRHR | |
| SCHEMBL9682469 | 0.78 | TBXA2R (0.62) | TBXA2RAGTR1AGTR2 | |
| SCHEMBL9581584 | 0.78 | TBXA2R (0.64) | TBXA2RAGTR1AGTR2 | |
| SCHEMBL9771980 | 0.74 | P2RX3 (0.43) | P2RX3KDM4EALDH1A1LMNAMAPK1 | |
| SCHEMBL9681858 | 0.73 | TBXA2R (0.77) | TBXA2RAGTR1AGTR2 | |
| SCHEMBL22965164 | 0.72 | FAAH (0.58) | AGTR1AGTR2KDM4EALDH1A1 | |
| SCHEMBL9699174 | 0.72 | PTGDR2 (0.55) | TBXA2RAGTR1AGTR2P2RX3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |