Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 12/20 | 0.57 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.55 |
| ▸ | GNRHR | P30968 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9581575 | 0.97 | TBXA2R (0.58) | TBXA2RPTGDR2GNRHRDRD2AGTR1 | |
| SCHEMBL9699174 | 0.93 | PTGDR2 (0.55) | TBXA2RPTGDR2GNRHRDRD2AGTR1 | |
| SCHEMBL9682889 | 0.87 | TBXA2R (0.64) | TBXA2RGNRHRDRD2AGTR1AGTR2 | |
| SCHEMBL5107355 | 0.85 | PTGDR2 (0.75) | PTGDR2 | |
| SCHEMBL9681428 | 0.84 | PTGDR2 (0.71) | TBXA2RPTGDR2DRD2 | |
| SCHEMBL9683250 | 0.84 | TBXA2R (0.66) | TBXA2RPTGDR2GNRHRDRD2AGTR1 | |
| SCHEMBL9771978 | 0.79 | TBXA2R (0.50) | TBXA2RGNRHRAGTR1AGTR2 | |
| SCHEMBL9771974 | 0.77 | TBXA2R (0.52) | TBXA2RGNRHRAGTR1AGTR2 | |
| SCHEMBL9682042 | 0.77 | PTGDR2 (0.53) | TBXA2RPTGDR2DRD2 | |
| SCHEMBL9700228 | 0.76 | ALDH1A1 (0.60) | TBXA2RPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |