Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9363838 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2MMP8GAACASRCYP1A2 | |
| SCHEMBL3840238 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2MMP8GAACASRCYP1A2 | |
| SCHEMBL6276114 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2MMP8GAACASRCYP1A2 | |
| SCHEMBL9773175 | 0.86 | HSD17B10 (0.44) | SMN1; SMN2MMP8CASRCYP1A2CYP2D6 | |
| SCHEMBL10603601 | 0.86 | SMN1; SMN2 (0.43) | SMN1; SMN2MMP8GAACASRTDP1 | |
| SCHEMBL9773237 | 0.86 | HSD17B10 (0.44) | SMN1; SMN2MMP8CASRCYP1A2CYP2D6 | |
| SCHEMBL8640339 | 0.84 | SMN1; SMN2 (0.44) | SMN1; SMN2MMP8GAACASRCYP1A2 | |
| SCHEMBL7257080 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2MMP8GAACASRCYP1A2 | |
| SCHEMBL20113912 | 0.81 | MMP8 (0.50) | SMN1; SMN2MMP8GAACASRTDP1 | |
| SCHEMBL9363415 | 0.81 | EPHX1 (0.49) | SMN1; SMN2CASRCYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5043346-A | Amino acid esters, pharmaceuticals containing them, and the use thereof in learning disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-27 | — | — | US | disclosed |