Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9773175 | 1.00 | HSD17B10 (0.44) | HSD17B10SMN1; SMN2LMNAL3MBTL1MMP8 | |
| SCHEMBL27300721 | 0.86 | HSD17B10 (0.48) | HSD17B10MAPTALDH1A1CTSB | |
| SCHEMBL6276114 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAL3MBTL1MMP8TDP1 | |
| SCHEMBL9773126 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAL3MBTL1MMP8TDP1 | |
| SCHEMBL3840238 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAL3MBTL1MMP8TDP1 | |
| SCHEMBL9363838 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAL3MBTL1MMP8TDP1 | |
| SCHEMBL10603601 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAL3MBTL1MMP8TDP1 | |
| SCHEMBL21077552 | 0.80 | ALDH1A1 (0.50) | HSD17B10SMN1; SMN2LMNAL3MBTL1TDP1 | |
| SCHEMBL20434152 | 0.80 | ALDH1A1 (0.50) | HSD17B10SMN1; SMN2LMNAL3MBTL1TDP1 | |
| SCHEMBL14985680 | 0.80 | METAP2 (0.43) | HSD17B10SMN1; SMN2LMNAL3MBTL1MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5043346-A | Amino acid esters, pharmaceuticals containing them, and the use thereof in learning disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-27 | — | — | US | disclosed |