Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 14/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL194895 | 1.00 | ACE (0.72) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| Maleic Acid SCHEMBL9773179 | 1.00 | ACE (0.72) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| Maleic Acid SCHEMBL9773197 | 0.97 | ACE (0.69) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL9775445 | 0.96 | ACE (0.77) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL9773138 | 0.96 | ACE (0.77) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL9593609 | 0.96 | ACE (0.77) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL9775474 | 0.96 | ACE (0.77) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL9773238 | 0.96 | ACE (0.77) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL9773120 | 0.96 | ACE (0.77) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL9773161 | 0.96 | ACE (0.77) | ACEMEN1KMT2ACYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5043346-A | Amino acid esters, pharmaceuticals containing them, and the use thereof in learning disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-27 | — | — | US | disclosed |