Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8014835 | 0.84 | LMNA (0.53) | CYP2C19NPC1RAB9AHSD11B1TP53 | |
| SCHEMBL11158191 | 0.80 | CYP2C19 (0.58) | CYP2C19RAB9ATP53KMT2ALMNA | |
| SCHEMBL23232300 | 0.78 | CYP2C19 (0.70) | CYP2C19NPC1RAB9ATP53KMT2A | |
| SCHEMBL28012695 | 0.78 | NPC1 (0.65) | NPC1RAB9AHSD11B1LMNAL3MBTL1 | |
| SCHEMBL28197598 | 0.78 | NPC1 (0.84) | NPC1RAB9AHSD11B1MEN1KMT2A | |
| SCHEMBL29275329 | 0.78 | NPC1 (0.55) | CYP2C19NPC1RAB9AHSD11B1MEN1 | |
| SCHEMBL8014833 | 0.78 | ALDH1A1 (0.56) | NPC1RAB9ATP53KMT2ALMNA | |
| SCHEMBL4485908 | 0.77 | RAB9A (0.69) | CYP2C19NPC1RAB9AHSD11B1MEN1 | |
| SCHEMBL9622180 | 0.76 | CYP2C19 (0.62) | CYP2C19NPC1RAB9ATP53MEN1 | |
| SCHEMBL44801 | 0.76 | CYP2C19 (1.00) | CYP2C19TP53KMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5075339-A | Antiinflammatory agents, antiallergens | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-24 | — | — | US | disclosed |
| US-4948813-A | Benzylketone phospholipase A2 inhibitors | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-08-14 | — | — | US | disclosed |