SCHEMBL9775712

SCHEMBL9775712

COc1ccc(Oc2ccc[c]c2-c2cccc(Oc3ccccc3C)c2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 3/20 0.44
ALDH1A1 P00352 4/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
CYP1A2 P05177 2/20 0.39
CYP2C9 P11712 2/20 0.39
CYP2C19 P33261 2/20 0.39
HPGD P15428 1/20 0.39
LTA4H P09960 1/20 0.39
HTT P42858 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
MAPK1 P28482 1/20 0.38
POLB P06746 1/20 0.38
GAA P10253 1/20 0.38
LMNA P02545 1/20 0.38
COMT P21964 1/20 0.37
ABL1 P00519 1/20 0.37
ABCB1 P08183 1/20 0.37
BCR P11274 1/20 0.37
FFAR1 O14842 1/20 0.36
SLC6A2 P23975 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6776995 0.88 COMT (0.40) ARALDH1A1SMN1; SMN2HPGDLTA4H
SCHEMBL16059029 0.79 MAOB (0.40) ALDH1A1CYP1A2CYP2C9CYP2C19HPGD
SCHEMBL9775715 0.79 AR (0.44) ARALDH1A1SMN1; SMN2CYP1A2CYP2C9
SCHEMBL3411791 0.79 CYP1A1 (0.45) CYP1A2CYP2C9CYP2C19MAPK1GAA
SCHEMBL7843209 0.79 DYRK1A (0.45) ALDH1A1CYP1A2CYP2C9CYP2C19GAA
SCHEMBL7017882 0.77 CYP1A2 (0.41) ALDH1A1SMN1; SMN2CYP1A2CYP2C9CYP2C19
SCHEMBL9374193 0.77 CYP11B2 (0.46) ALDH1A1SMN1; SMN2CYP1A2CYP2C9CYP2C19
SCHEMBL2321472 0.77 ALDH1A1 (0.61) ARALDH1A1SMN1; SMN2CYP1A2CYP2C9
SCHEMBL5609585 0.75 AR (0.55) ARALDH1A1SMN1; SMN2HTTL3MBTL1
SCHEMBL2091154 0.74 TSHR (0.42) ALDH1A1HPGDLTA4HHTTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5002957-A Insecticides, acaricides, nematocides HOECHST AKTIENGESELLSCHAFT (DE) 1991-03-26 US disclosed