Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.43 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.41 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HTR3A | P46098 | 3/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.45 |
| ▸ | HTR3B | O95264 | 2/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9775796 | 1.00 | KDM4E (0.54) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| Fumaric Acid SCHEMBL9775801 | 1.00 | KDM4E (0.54) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL19902668 | 0.91 | KDM4E (0.57) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL19902669 | 0.81 | KDM4E (0.56) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL18313403 | 0.79 | KDM4E (0.57) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL30251861 | 0.77 | KDM4E (0.62) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL496589 | 0.77 | KDM4E (0.62) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| Fumaric Acid SCHEMBL9655988 | 0.76 | HTR3A (0.59) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| Maleic Acid SCHEMBL9655984 | 0.76 | HTR3A (0.59) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| Hydrochloric Acid SCHEMBL1563376 | 0.76 | KDM4E (0.60) | KDM4EHTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5019586-A | 5-Hydroxytryptamine Receptor Antagonists | GLAXO GROUP LIMITED | 1991-05-28 | — | — | US | disclosed |