Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 3/20 | 0.35 |
| ▸ | CTSA | P10619 | 3/20 | 0.35 |
| ▸ | CTSL | P07711 | 3/20 | 0.35 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.35 |
| ▸ | HTR3B | O95264 | 2/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9656237 | 0.70 | HTR3A (0.47) | GABRR1HTR3AHTR3EHTR3BHTR3D | |
| Maleic Acid SCHEMBL9656231 | 0.70 | HTR3A (0.47) | GABRR1HTR3AHTR3EHTR3BHTR3D | |
| Fumaric Acid SCHEMBL9657347 | 0.62 | HTR3E (0.53) | GABRR1HTR3AHTR3EHTR3BHTR3D | |
| Maleic Acid SCHEMBL9657342 | 0.62 | HTR3E (0.53) | GABRR1HTR3AHTR3EHTR3BHTR3D | |
| Oxalic Acid SCHEMBL5157364 | 0.61 | GABRR1 (0.61) | GABRR1HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6736196 | 0.61 | HRH4 (0.44) | GABRR1HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL7763092 | 0.61 | CTSK (0.49) | PPARGPPARACTSACTSLCTSK | |
| SCHEMBL11336370 | 0.61 | GABRR1 (0.47) | GABRR1HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL20553863 | 0.60 | AKR1C3 (0.51) | PPARGPPARACTSLCTSKCTSS | |
| SCHEMBL23870893 | 0.60 | GABRR1 (0.47) | GABRR1HTR3ACTSLCTSKHTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5019586-A | 5-Hydroxytryptamine Receptor Antagonists | GLAXO GROUP LIMITED | 1991-05-28 | — | — | US | disclosed |