Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9775877 | 0.91 | ADRB2 (0.43) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| SCHEMBL9775878 | 0.90 | KDM4E (0.51) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| SCHEMBL9786129 | 0.89 | DPP4 (0.44) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| SCHEMBL9775887 | 0.89 | ALDH1A1 (0.62) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| SCHEMBL8941950 | 0.87 | ADRB2 (0.44) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| SCHEMBL9775934 | 0.86 | KMT2A (0.46) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| SCHEMBL6784057 | 0.85 | KCNH2 (0.66) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| SCHEMBL9786218 | 0.85 | KDM4E (0.38) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| SCHEMBL7230077 | 0.84 | ADRB2 (0.50) | KDM4EHPGDALDH1A1HSD17B10ADRB2 | |
| SCHEMBL9786219 | 0.79 | KDM4E (0.41) | KDM4EHPGDALDH1A1KCNH2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |
| US-4970213-A | Benzo(1,8)naphthyridine derivatives as intermediates | RHONE-POULENC SANTE (FR) | 1990-11-13 | — | — | US | disclosed |