Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9775927 | 0.97 | LMNA (0.42) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775904 | 0.90 | LMNA (0.56) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9786183 | 0.90 | KMT2A (0.42) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL9775878 | 0.89 | KDM4E (0.51) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775972 | 0.89 | LMNA (0.42) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775877 | 0.88 | ADRB2 (0.43) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775892 | 0.88 | LMNA (0.53) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775884 | 0.87 | LMNA (0.52) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL8942151 | 0.85 | STAT3 (0.45) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9786170 | 0.84 | KDM4E (0.41) | LMNACYP2C9ATP6V1B2TBXA2REDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |