Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.53 |
| ▸ | EDNRA | P25101 | 1/20 | 0.53 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9775904 | 0.97 | LMNA (0.56) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775927 | 0.91 | LMNA (0.42) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775918 | 0.90 | LMNA (0.66) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775898 | 0.88 | LMNA (0.44) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775896 | 0.88 | ALDH1A1 (0.49) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775882 | 0.86 | LMNA (0.70) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775972 | 0.85 | LMNA (0.42) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775877 | 0.85 | ADRB2 (0.43) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775932 | 0.82 | ALDH1A1 (0.54) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL11026728 | 0.81 | LMNA (0.79) | LMNACYP2C9ATP6V1B2TBXA2REDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |