Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9786144 | 0.88 | KMT2A (0.47) | STAT3KMT2AALDH1A1TSHRHTT | |
| SCHEMBL9775932 | 0.88 | ALDH1A1 (0.54) | KMT2AALDH1A1TSHRHTTKDM4E | |
| SCHEMBL9775866 | 0.86 | STAT3 (0.43) | STAT3KMT2AALDH1A1TSHRHTT | |
| SCHEMBL9786183 | 0.86 | KMT2A (0.42) | STAT3KMT2ABAZ2BBAZ2AALDH1A1 | |
| SCHEMBL7234823 | 0.85 | KMT2A (0.47) | STAT3KMT2ABAZ2BBAZ2AALDH1A1 | |
| SCHEMBL9775898 | 0.85 | LMNA (0.44) | STAT3KMT2AALDH1A1TSHRHTT | |
| SCHEMBL8941989 | 0.85 | LMNA (0.40) | KMT2AALDH1A1HTTMAP2K1KDM4E | |
| SCHEMBL7230077 | 0.84 | ADRB2 (0.50) | STAT3KMT2AALDH1A1TSHRHTT | |
| SCHEMBL7229828 | 0.83 | MAPT (0.45) | STAT3KMT2AALDH1A1TSHRHTT | |
| SCHEMBL9775927 | 0.82 | LMNA (0.42) | STAT3KMT2AALDH1A1TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0379414-B1 | 1,8-Benzonaphthyridine derivatives and their preparation | BELLON LABOR SA ROGER (FR) | 1993-12-22 | — | — | EP | claimed |
| US-4970213-A | Benzo(1,8)naphthyridine derivatives as intermediates | RHONE-POULENC SANTE (FR) | 1990-11-13 | — | — | US | claimed |
| US-5556861-A | 1,8 benzonaphthyridine derivatives and antimicrobial compositions | LABORATOIRE ROGER BELLON (FR) | 1996-09-17 | — | — | US | disclosed |
| US-5053509-A | Microbiocides; AIDS | LABORATOIRE ROGER BELLON (FR) | 1991-10-01 | — | — | US | disclosed |
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |
| US-4990515-A | Chemical intermediates | RHONE-POULENC SANTE (FR) | 1991-02-05 | — | — | US | disclosed |
| US-4970213-A | Benzo(1,8)naphthyridine derivatives as intermediates | RHONE-POULENC SANTE (FR) | 1990-11-13 | — | — | US | disclosed |