Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8030818 | 0.69 | CYP3A4 (0.65) | MAPTADRA2AADRA2BADRA2CADRA1A | |
| Talipexole SCHEMBL49817 | 0.69 | DRD2 (1.00) | MAPTADRA2AADRA2BADRA2CADRA1A | |
| Talipexole SCHEMBL5605621 | 0.69 | DRD2 (1.00) | MAPTADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL8114306 | 0.69 | ADRA2A (0.43) | MAPTADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL1478430 | 0.69 | ADRA2A (0.43) | MAPTADRA2AADRA2BADRA2CADRA1A | |
| Hydrochloric Acid SCHEMBL10656025 | 0.68 | LMNA (0.66) | MAPTADRA2AADRA2BADRA2CADRA1A | |
| Talipexole SCHEMBL423325 | 0.68 | MAPT (1.00) | MAPTADRA2AADRA2BADRA2CADRA1A | |
| Hydrochloric Acid SCHEMBL11074146 | 0.68 | MAPT (0.54) | MAPTADRA2AADRA2BADRA2CADRA1A | |
| Talipexole SCHEMBL18203528 | 0.68 | MAPT (1.00) | MAPTADRA2AADRA2BADRA2CADRA1A | |
| Talipexole SCHEMBL385161 | 0.68 | MAPT (1.00) | MAPTADRA2AADRA2BADRA2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5030630-A | Use of 6-allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine- for treating diseases caused by reduced secretion of growth hormone | BOEHRINGER INGELHEIM KG (DE) | 1991-07-09 | — | — | US | claimed |