Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9338507 | 0.94 | APP (0.48) | APPCYP1B1MAOAMAOBEGFR | |
| SCHEMBL9337744 | 0.86 | MAPT (0.42) | CYP1B1MAOAMAOBEGFRMAPT | |
| SCHEMBL9342457 | 0.86 | MAOA (0.54) | CYP1B1MAOAMAOBEGFRMAPT | |
| SCHEMBL9337686 | 0.83 | HSD17B3 (0.54) | CYP1B1MAOAMAOBEGFRMAPT | |
| SCHEMBL9337604 | 0.83 | MMP1 (0.56) | CYP1B1MAOAMAOBMAPTMMP1 | |
| SCHEMBL9339436 | 0.82 | NFE2L2 (0.61) | CYP1B1MAOAMAOBEGFRMAPT | |
| SCHEMBL9341559 | 0.82 | CYP1A2 (0.53) | CYP1B1MAOAMAOBMAPTALDH1A1 | |
| SCHEMBL9778908 | 0.81 | MAPT (0.51) | APPCYP1B1MAOAMAOBEGFR | |
| SCHEMBL9338542 | 0.80 | CYP1B1 (0.64) | CYP1B1MAOAMAOBEGFRMAPT | |
| SCHEMBL9338474 | 0.80 | MAPT (0.44) | CYP1B1MAOAMAOBEGFRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045239-A | Chalcone derivative | NIPPON OIL AND FATS CO., LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0328669-A1 | CHALCONE DERIVATIVE COMPOUNDS | NIPPON OIL AND FATS COMPANY, LIMITED (JP) | 1989-08-23 | — | — | EP | disclosed |