Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 10/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869390 | 0.84 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDRECQLMAPT | |
| SCHEMBL977917 | 0.81 | ACHE (0.43) | ALDH1A1KDM4EHPGDRECQLMAPT | |
| SCHEMBL7486918 | 0.80 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDRECQLMAPT | |
| SCHEMBL15058559 | 0.76 | ALDH1A1 (0.62) | ALDH1A1KDM4EHPGDRECQLMAPT | |
| SCHEMBL5780390 | 0.71 | ALDH1A1 (0.70) | ALDH1A1KDM4EHPGDRECQLMAPT | |
| SCHEMBL870500 | 0.71 | ALDH1A1 (0.70) | ALDH1A1KDM4EHPGDRECQLMAPT | |
| SCHEMBL4856578 | 0.71 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDRECQLMAPT | |
| SCHEMBL7317599 | 0.70 | CYP11B2 (0.44) | ALDH1A1KDM4EHPGDRECQLMAPT | |
| SCHEMBL5766977 | 0.70 | ALDH1A1 (0.70) | ALDH1A1KDM4EHPGDRECQLMAPT | |
| SCHEMBL5821038 | 0.70 | ALDH1A1 (0.70) | ALDH1A1KDM4EHPGDRECQLMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448934-A1 | 2-CARBOXAMIDE-7-PIPERAZINYL-BENZOFURAN DERIVATIVES 774 | AstraZeneca AB (SE) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011002405-A1 | 2-CARBOXAMIDE-7-PIPERAZINYL-BENZOFURAN DERIVATIVES 774 | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |