Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL977916 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDRECQLMAPT | |
| SCHEMBL869390 | 0.77 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDRECQLMAPT | |
| SCHEMBL7486918 | 0.73 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDRECQLMAPT | |
| SCHEMBL5647712 | 0.72 | ALDH1A1 (0.59) | ALDH1A1KDM4EMAPTRAB9ACYP2D6 | |
| SCHEMBL15058559 | 0.72 | ALDH1A1 (0.62) | ALDH1A1KDM4EHPGDRECQLMAPT | |
| SCHEMBL7317599 | 0.71 | CYP11B2 (0.44) | ALDH1A1KDM4EHPGDRECQLMAPT | |
| SCHEMBL7482667 | 0.71 | MCHR1 (0.45) | ALDH1A1KDM4EMAPTGNG2GNB1 | |
| SCHEMBL27611315 | 0.69 | ACHE (0.57) | ACHEALDH1A1KDM4EHPGDRECQL | |
| SCHEMBL20178650 | 0.69 | ACHE (0.54) | ACHEALDH1A1KDM4EHPGDRECQL | |
| SCHEMBL4809452 | 0.68 | MAPT (0.64) | MAPTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448934-A1 | 2-CARBOXAMIDE-7-PIPERAZINYL-BENZOFURAN DERIVATIVES 774 | AstraZeneca AB (SE) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011002405-A1 | 2-CARBOXAMIDE-7-PIPERAZINYL-BENZOFURAN DERIVATIVES 774 | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |