Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | PYGL | P06737 | 1/20 | 0.54 |
| ▸ | PPARA | Q07869 | 3/20 | 0.49 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9780857 | 0.98 | KMT2A (0.61) | KMT2APYGLPPARALTB4RHPGD | |
| SCHEMBL9780586 | 0.95 | KMT2A (0.65) | KMT2APYGLHPGDL3MBTL1AKR1B1 | |
| SCHEMBL9780958 | 0.89 | KMT2A (0.67) | KMT2APYGLL3MBTL1AKR1B1MEN1 | |
| SCHEMBL27634252 | 0.88 | KMT2A (0.49) | KMT2APYGLPPARALTB4RSERPINE1 | |
| SCHEMBL9501831 | 0.83 | POLB (0.56) | KMT2AHPGDL3MBTL1 | |
| SCHEMBL27654735 | 0.83 | MAPT (0.45) | KMT2APYGLLTB4RL3MBTL1MEN1 | |
| SCHEMBL3168428 | 0.81 | MEN1 (0.57) | KMT2APPARALTB4RHPGDL3MBTL1 | |
| SCHEMBL9322243 | 0.79 | MEN1 (0.55) | KMT2APYGLPPARALTB4RHPGD | |
| SCHEMBL15048558 | 0.79 | ALDH1A1 (0.51) | KMT2APPARAL3MBTL1MEN1 | |
| Adipic Acid SCHEMBL10476896 | 0.78 | HDAC3 (0.57) | KMT2AL3MBTL1AKR1B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257378-B1 | PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1991-07-03 | — | — | EP | disclosed |
| US-5010060-A | Method of treating herpes simplex viral infection employing pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-04-23 | — | — | US | disclosed |
| US-4851519-A | AMIDO NUCLEOSIDES, VIRICIDES | HOFFMANN-LA ROCHE INC. (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0257378-A1 | Pyrimidine derivatives, their preparation and medicaments containing these derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-03-02 | — | — | EP | disclosed |