Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | PYGL | P06737 | 1/20 | 0.56 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.49 |
| ▸ | PPARA | Q07869 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9780778 | 0.98 | KMT2A (0.62) | KMT2APYGLLTB4RPPARASERPINE1 | |
| SCHEMBL9780586 | 0.93 | KMT2A (0.65) | KMT2APYGLHPGDL3MBTL1AKR1B1 | |
| SCHEMBL27634252 | 0.89 | KMT2A (0.49) | KMT2APYGLLTB4RPPARAMAPT | |
| SCHEMBL9780958 | 0.87 | KMT2A (0.67) | KMT2APYGLL3MBTL1AKR1B1 | |
| SCHEMBL27654735 | 0.84 | MAPT (0.45) | KMT2APYGLLTB4RMAPTALDH1A1 | |
| SCHEMBL9501831 | 0.82 | POLB (0.56) | KMT2AMAPTHPGDL3MBTL1 | |
| SCHEMBL9322243 | 0.81 | MEN1 (0.55) | KMT2APYGLLTB4RPPARAMAPT | |
| SCHEMBL6575170 | 0.80 | PYGL (0.51) | PYGLLTB4RALDH1A1ALB | |
| SCHEMBL20678420 | 0.79 | LTB4R (0.48) | PYGLLTB4RPPARAMAPTRXFP1 | |
| SCHEMBL3168428 | 0.79 | MEN1 (0.57) | KMT2ALTB4RPPARAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257378-B1 | PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1991-07-03 | — | — | EP | disclosed |
| US-5010060-A | Method of treating herpes simplex viral infection employing pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-04-23 | — | — | US | disclosed |
| US-4851519-A | AMIDO NUCLEOSIDES, VIRICIDES | HOFFMANN-LA ROCHE INC. (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0257378-A1 | Pyrimidine derivatives, their preparation and medicaments containing these derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-03-02 | — | — | EP | disclosed |